Simultaneous Viral Exposure and Protection from Neanderthal Introgression
نویسندگان
چکیده
منابع مشابه
The Strength of Selection against Neanderthal Introgression
Hybridization between humans and Neanderthals has resulted in a low level of Neanderthal ancestry scattered across the genomes of many modern-day humans. After hybridization, on average, selection appears to have removed Neanderthal alleles from the human population. Quantifying the strength and causes of this selection against Neanderthal ancestry is key to understanding our relationship to Ne...
متن کاملThe Genetic Cost of Neanderthal Introgression.
Approximately 2-4% of genetic material in human populations outside Africa is derived from Neanderthals who interbred with anatomically modern humans. Recent studies have shown that this Neanderthal DNA is depleted around functional genomic regions; this has been suggested to be a consequence of harmful epistatic interactions between human and Neanderthal alleles. However, using published estim...
متن کاملA deterministic model of admixture and genetic introgression: the case of Neanderthal and Cro-Magnon.
There is an ongoing debate in the field of human evolution about the possible contribution of Neanderthals to the modern human gene pool. To study how the Neanderthal private alleles may have spread over the genes of Homo sapiens, we propose a deterministic model based on recursive equations and ordinary differential equations. If the Neanderthal population was large compared to the Homo sapien...
متن کاملFrom Neanderthal to Homo sapiens
Project background During the course of evolution, the human brain has undergone tremendous expansion. This has led to the development of complex neurocircuits of unmatched complexity, highly social behaviour, expanded language use and cognitive superiority. A small number of infants, however, are born with significantly smaller brains, a condition called primary microcephaly (PM). Infants with...
متن کاملNeanderthal introgression at chromosome 3p21.31 was under positive natural selection in East Asians.
Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here, we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a low frequency in Europeans. We also detected a signal of strong positive selection in this region only in East As...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.09.019